Zvi Grossman, Tel Aviv University
NBRL seminar room (Fishbach 430) at 12:00
11 April, 2010
Dynamic tuning of cellular response characteristics in the immune system and beyond: concept and mechanisms
Lymphocytes respond to antigenic signals differentially based on the strength and time-contingency of the signals. When "resting", the cells continuously readjust their activation thresholds to the level of stimulation in order to maintain tolerance to self and avoid chance activation. The molecular mechanisms underlying such differential responses and tuning involve competition between excitation and de-excitation processes that possess inherently different kinetics. More generally, dynamic tuning in cell biology is required not only to distinguish signals from "noise" but also as a major component in the homeostatic regulation of cell numbers, differentiation and function.